Smaller Cas Proteins Aid Gene Editing Delivery
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Feng Zhang on Peter Attia's podcast, October 28, 2024
General HealthContent
Story of claim
Smaller Cas proteins like IscB, only 450 amino acids, enhance delivery in gene editing, improving therapy efficiency.
- Goal: Develop smaller proteins for more efficient gene delivery.
- Proof: Smaller proteins are more easily packaged, improving delivery and gene editing efficacy.
- Nuances:
- Cas9 is 1,300 amino acids, challenging for delivery.
- IscB is an ancestral form, only 450 amino acids.
- Impact on Life: May lead to more accessible genetic therapies and reduce treatment costs.
Investments
- Price: Not mentioned
- Time: Not mentioned
- Effort: Requires advanced protein engineering and validation.
Risks
Potential loss of function with smaller proteins if not properly engineered.
Get Started 🚀
- Research current small Cas proteins.
- Collaborate with protein engineers.
- Test delivery efficiency in lab settings.
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