Rapamycin Promises Longevity, Needs Human Trials

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Peter Attia MD discusses rapamycin's potential as a geroprotective drug.

Quotes From Source

“Rapa extended life in male mice, female mice...”

Story of claim

Rapamycin, discovered in the 60s, extends lifespan in animals by inhibiting mTOR. Its geroprotective potential in humans remains unproven due to insufficient human studies.

  • Goal: Evaluate rapamycin's promise in extending lifespan.
  • Proof: Rapamycin extends life in multiple species by inhibiting mTOR, but lacks human evidence for similar effects.
  • Nuances:
    • Discovered on Easter Island in the mid-60s.
    • Initially used for organ transplantation in 1999.
    • ITP study replicated in multiple species.
    • Short-term human studies show immune enhancement.
  • Impact on Life: If proven, rapamycin could extend human lifespan, potentially delaying aging-related diseases.

Investments

  • Price:
  • Time:
  • Effort: Understanding of risks and probabilities is essential.

Risks

Potential unknown long-term effects in humans.

Alternatives

  • Metformin, another potential geroprotective drug.

Get Started 🚀

  • Consult a healthcare professional before considering rapamycin.
  • Research existing studies on rapamycin's effects.
  • Consider lifestyle changes that promote longevity.

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Reference Video