Protein Depletion May Trigger Autophagy

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingDiet

Quotes From Source

“Can you limit protein intake for a week to induce autophagy?”

Story of claim

Dr. Kroemer discusses how reducing protein intake can potentially trigger autophagy by affecting insulin growth factors. Tested on mice and humans, this method can help induce cellular cleanup.

  • Goal: To induce autophagy through selective nutrient depletion.
  • Proof: Protein depletion affects insulin growth factors, potentially inducing autophagy, though not thoroughly tested in mice.
  • Nuances:
    • Tested on completely starved mice and human volunteers.
    • Brain cells are buffered against nutrient depletion effects.
  • Impact on Life: By inducing autophagy, individuals might experience anti-aging benefits through cellular cleanup, potentially reducing age-related damage.

Investments

  • Price: Estimation: $0 (involves diet change)
  • Time: Duration of diet change varies, typically a week.
  • Effort: Requires discipline to maintain reduced protein intake.

Risks

Prolonged nutrient depletion can have adverse effects; brain cells may be less affected, but caution is needed.

Alternatives

  • Consider intermittent fasting as a method to induce autophagy
  • Exercise may also stimulate autophagy

Get Started 🚀

  • Attempt a low-protein diet for a week.
  • Monitor energy levels and body response.
  • Consult a nutritionist if planning long-term changes.

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Reference Video