Rapamycin Induces Autophagy Without Deacetylation

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingMedical

Quotes From Source

“Pharmacological tricks can induce autophagy without deacetylation.”

Story of claim

Dr. Kroemer explains how pharmacological methods, like rapamycin, can induce autophagy without requiring protein deacetylation, providing alternative routes to stimulate cellular cleanup.

  • Goal: To induce autophagy without protein deacetylation.
  • Proof: Rapamycin can induce autophagy without protein deacetylation, offering an alternative pathway.
  • Nuances:
    • LC3 redistribution is used to study autophagy.
    • Immunofluorescence shows LC3 redistribution as punctate dots.
  • Impact on Life: Pharmacological induction of autophagy can lead to cellular health improvements without dietary changes.

Investments

  • Price: Rapamycin or similar drugs may require a prescription.
  • Time: Effectiveness and duration depend on dosage and individual response.
  • Effort: Requires medical supervision for safe use.

Risks

Potential side effects from rapamycin or pharmacological agents; medical guidance recommended.

Alternatives

  • Dietary methods like fasting to induce autophagy
  • Exercise as a natural stimulator of autophagy

Get Started 🚀

  • Consult with a healthcare provider about rapamycin.
  • Consider other pharmacological options if advised.
  • Regularly monitor for any side effects.

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