PAM Sequences Protect Bacteria from Self-Targeting

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Feng Zhang discusses the protective role of PAM sequences in CRISPR systems.

General HealthContent

Quotes From Source

The PAM sequence is only found in the viral genome...

Story of claim

PAM sequences prevent CRISPR from mistakenly cleaving the host's own DNA by differentiating bacterial DNA from viral DNA, ensuring safe operation of the CRISPR system.

  • Goal: Prevent CRISPR from attacking bacterial DNA.
  • Proof: PAM sequences ensure that CRISPR systems do not mistakenly target the host's own DNA.
  • Nuances:
    • PAM prevents CRISPR from self-targeting.
    • PAM is crucial for activation of recognition and cleavage.
  • Impact on Life: N/A

Investments

  • Price: N/A
  • Time: N/A
  • Effort: N/A

Risks

Requires precise identification of PAM sequences to prevent self-targeting.

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