Niacinamide Temporarily Inhibits SIRT1, Boosts NAD Long Term
S
Siim Land's YouTube Q&A session on November 22, 2024
Story of claim
Siim Land explains that niacinamide initially inhibits SIRT1 but ultimately boosts NAD levels, which in turn stimulates SIRT1 activity over time.
- Goal: Utilize niacinamide to enhance NAD levels while managing SIRT1 activity effects.
- Proof: Niacinamide's conversion to NAD helps stimulate SIRT1 long term, despite temporary inhibition.
- Nuances:
- No evidence suggests SIRT1 inhibition harms long-term health
- SIRT1 overexpression hasn't extended lifespan in studies
- Impact on Life: Boosting NAD may improve cellular health and energy metabolism.
Investments
- Price: $10-$20 for niacinamide supplements
- Time: Daily supplementation
- Effort: Minimal; involves regular supplement intake
Risks
Potential temporary inhibition of SIRT1, but not shown to harm long-term health.
Alternatives
- NMN or NR supplements for NAD boosting
- Engage in lifestyle changes like exercise to naturally boost NAD
Get Started 🚀
- Purchase niacinamide supplements
- Take as directed to support NAD levels
- Monitor any changes in energy levels
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