Easier to Study Autophagy in Rodents

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingTesting

Quotes From Source

“Finding the minimum fasting time for autophagy is difficult in humans.”

Story of claim

Dr. Kroemer explains the challenge in determining the minimum fasting time for autophagy in humans due to the difficulty in obtaining volunteers for invasive biopsies.

  • Goal: Identify minimum fasting time for autophagy activation.
  • Proof: Rodents provide a more accessible model for studying autophagy due to their metabolic characteristics and easier sampling.
  • Nuances:
    • IGF-1 half-life is around 12 hours in serum.
    • Lowering IGF-1 is important for inducing autophagy.
  • Impact on Life: Potential for optimized fasting schedules to activate autophagy, aiding in anti-aging strategies.

Investments

  • Price:
  • Time: No specific duration is universally established for humans
  • Effort: Requires commitment to fasting and possibly invasive testing in research settings.

Risks

Lack of human volunteers for studies may delay understanding of optimal fasting durations.

Alternatives

  • Non-invasive biomarkers for autophagy detection
  • Using animal models for preliminary insights

Get Started 🚀

  • Explore fasting schedules that fit your lifestyle and health goals.
  • Consider starting with intermittent fasting to ease into longer fasts.
  • Stay informed on emerging research to optimize fasting practices.

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Reference Video