Easier to Study Autophagy in Rodents
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Dr. Guido Kroemer on Rhonda Patrick's podcast
Anti-AgingTesting
Story of claim
Dr. Kroemer explains the challenge in determining the minimum fasting time for autophagy in humans due to the difficulty in obtaining volunteers for invasive biopsies.
- Goal: Identify minimum fasting time for autophagy activation.
- Proof: Rodents provide a more accessible model for studying autophagy due to their metabolic characteristics and easier sampling.
- Nuances:
- IGF-1 half-life is around 12 hours in serum.
- Lowering IGF-1 is important for inducing autophagy.
- Impact on Life: Potential for optimized fasting schedules to activate autophagy, aiding in anti-aging strategies.
Investments
- Price:
- Time: No specific duration is universally established for humans
- Effort: Requires commitment to fasting and possibly invasive testing in research settings.
Risks
Lack of human volunteers for studies may delay understanding of optimal fasting durations.
Alternatives
- Non-invasive biomarkers for autophagy detection
- Using animal models for preliminary insights
Get Started 🚀
- Explore fasting schedules that fit your lifestyle and health goals.
- Consider starting with intermittent fasting to ease into longer fasts.
- Stay informed on emerging research to optimize fasting practices.
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