Metformin and Autophagy Drugs for Aging

D

Dr. David Perlmutter, Executive Vice Chancellor for Medical Affairs and Dean, School of Medicine, Washington University in St. Louis

Anti-AgingGeneral HealthMedical

Quotes From Source

“Metformin prolongs life in experimental animals...”

Story of claim

Metformin and autophagy-targeting drugs show potential in extending lifespan and combating age-related conditions, though effects on autophagy are not yet evidenced.

  • Goal: To explore the therapeutic potential of metformin and autophagy-targeting drugs.
  • Proof: Metformin prolongs life in experimental animals, and drugs targeting autophagy pathways hold promise for therapy.
  • Nuances:
    • Metformin's effect on autophagy not yet evidenced
    • Panel of potential agents for age-dependent degeneration
  • Impact on Life: May contribute to increased lifespan and improved health span, aligning with anti-aging goals.

Investments

  • Price: $10-20 per month for metformin
  • Time: Long-term commitment for potential benefits
  • Effort: Requires medical supervision and ongoing research

Risks

Potential side effects of metformin include gastrointestinal discomfort. Long-term impact on autophagy unknown.

Alternatives

  • Lifestyle changes like caloric restriction and exercise
  • Other anti-aging medications under research

Get Started 🚀

  • Consult with a healthcare provider about metformin
  • Research autophagy-targeting drugs if available
  • Consider lifestyle changes to support autophagy
  • Monitor health markers regularly

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Reference Video