Liver's Lipid Recycling Enhances CRISPR Delivery

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Peter Attia MD podcast episode with Feng Zhang

General HealthContent

Quotes From Source

“A lot of lipid recycling happens in the liver...”

Story of claim

Feng Zhang highlights the liver's lipid recycling as optimal for CRISPR delivery using lipid nanoparticles. This method targets liver cells effectively for genetic therapies.

  • Goal: To leverage the liver's natural lipid recycling for efficient CRISPR delivery in gene therapies.
  • Proof: The liver's lipid recycling properties facilitate efficient uptake and delivery of lipid nanoparticles, enhancing CRISPR therapy targeting.
  • Nuances:
    • Liver filters toxins, aiding in nanoparticle uptake
    • Intravenous delivery channels lipid nanoparticles to the liver
  • Impact on Life: Could lead to effective treatments for genetic liver diseases, improving patient outcomes.

Investments

  • Price: Not specified
  • Time: Ongoing research and development
  • Effort: High due to technological and biological challenges

Risks

Possible off-target genetic modifications.

Get Started 🚀

  • Focus research on lipid nanoparticle development
  • Target liver-specific genetic therapies
  • Consider intravenous delivery methods

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