Ketamine Causes Disinhibition in Frontal Lobe
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Dr. Jon Berner's interview on Longevity & Aging Series (S2, E3)
Mental HealthMedical
Story of claim
Ketamine affects inhibitory GABAergic interneurons, leading to disinhibition in the frontal lobe, which may result in psychoactive experiences.
- Goal: Explore the neurological impacts of ketamine, particularly its effects on mood and perception.
- Proof: Ketamine's binding to NMDA receptors on parvalbumin positive interneurons leads to disinhibition.
- Nuances:
- High proportion of patients respond without delirium.
- Effects vary widely among individuals.
- Impact on Life: Can provide relief for chronic pain and mood disorders, potentially improving quality of life.
Investments
- Price: $300 for ketamine treatment sessions
- Time: Varies per patient session
- Effort: Requires careful patient monitoring for effects
Risks
Possible delirium or psychoactive experiences. Effects are not universally understood.
Alternatives
- Traditional antidepressants or pain management therapies
Get Started 🚀
- Consult with a psychiatrist specialized in ketamine treatment.
- Administer ketamine under professional supervision.
- Monitor changes in neural activity and patient reports.
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