Incorporate Immune Challenges in Longevity Studies

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Dr. Aubrey de Grey's presentation at the International Longevity Alliance

ImmunityTesting

Quotes From Source

“A tremendous amount of disease is due to infectious diseases.”

Story of claim

Dr. Aubrey de Grey suggests adding controlled immune challenges to animal longevity studies to better mimic real-life conditions. This approach addresses the role of infectious diseases in aging research.

  • Goal: To enhance the realism of longevity studies by introducing immune challenges that animals face in real-life scenarios.
  • Proof: Dr. de Grey states that adding immune challenges could address a significant confounder in current longevity research, as many diseases are due to infections.
  • Nuances:
    • Exercise is crucial to prevent mice boredom and obesity.
    • Plan to use running wheels in cages for exercise.
    • Standardizing immune challenges is complex and may affect experiment interpretation.
  • Impact on Life: This approach could lead to more accurate longevity research outcomes, potentially impacting future human aging treatments.

Investments

  • Price: Estimation: $50,000-100,000 per study to include immune challenges
  • Time: Several months to design and implement new study protocols
  • Effort: Requires collaboration with immunologists and careful planning

Risks

Standardizing immune challenges is complex and might introduce new variables that complicate study results.

Get Started 🚀

  • Collaborate with immunologists to design immune challenges.
  • Implement running wheels in cages to promote exercise.
  • Standardize infection doses for uniform immune challenges.
  • Evaluate study design for potential confounding factors.

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Reference Video