4-Day Fast in Humans vs. 2-Day in Rodents

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingLifestyle

Quotes From Source

“In 4 days, a human loses 1-2% of weight vs. 20% in mice over 2 days.”

Story of claim

Dr. Guido Kroemer discusses the differences in weight loss due to fasting between humans and rodents. Humans lose 1-2% of weight in 4 days, while rodents lose 20% in 2 days due to higher metabolism.

  • Goal: Understanding weight loss differences in fasting between humans and rodents.
  • Proof: Rodents experience higher metabolism linked to surface volume ratio, causing drastic weight loss.
  • Nuances:
    • Weight loss in mice at verge of death after 2 days without food.
    • Metabolism differences affect fasting outcomes between species.
  • Impact on Life: The insights could potentially influence fasting practices for weight loss in humans.

Investments

  • Price:
  • Time: 4-day fasting for humans, 2-day for rodents
  • Effort: Fasting requires significant discipline and may impact daily activities.

Risks

Prolonged fasting can be dangerous, especially in rodents, due to potential starvation.

Alternatives

  • Caloric restriction as a more sustainable alternative
  • Intermittent fasting for manageable weight control

Get Started 🚀

  • Consult with a healthcare provider before starting a fasting regimen.
  • Begin with shorter fasting periods to adapt your body.
  • Monitor your body's response and adjust fasting duration accordingly.

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