Fasting Stimulates Autophagy in Humans
D
Dr. Guido Kroemer on Rhonda Patrick's podcast
Anti-AgingLifestyle
Story of claim
Dr. Kroemer explains that fasting can induce autophagy, with evidence suggesting a 48-hour fast in rodents is equivalent to 4 days in humans.
- Goal: To induce autophagy through fasting.
- Proof: Fasting can trigger autophagy in rodents and humans; however, the minimum fasting time for autophagy activation is unknown.
- Nuances:
- Time-restricted eating schedule varies among individuals.
- Circadian variations in hepatic autophagy noted in mice.
- Impact on Life: Fasting may enhance cellular health and longevity through autophagy, potentially improving metabolic functions.
Investments
- Price: Cost of fasting is negligible.
- Time: Varies, but typically 4 days of fasting for significant effects.
- Effort: Requires significant discipline and lifestyle adjustment.
Risks
Extended fasting can be challenging and may require medical supervision, especially for those with health conditions.
Alternatives
- Caloric restriction as a long-term strategy
- Exercise-induced autophagy as a complement
Get Started 🚀
- Begin with intermittent fasting (e.g., 16/8 schedule).
- Gradually extend fasting duration to 24-48 hours.
- Monitor body response and consult a professional if needed.
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