CRISPR Inactivates Overexpressed Genes in Disease

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Peter Attia's podcast with Feng Zhang on October 28, 2024

General HealthContent

Quotes From Source

“Certain proteins in the liver cause fibrosis...”

Story of claim

Feng Zhang discusses using CRISPR to inactivate genes that cause diseases by overexpression, like liver fibrosis, by cleaving them to halt toxic protein production.

  • Goal: To treat diseases by stopping the production of harmful proteins caused by overexpressed genes.
  • Proof: Inactivating overexpressed genes can stop the production of toxic proteins, potentially treating related diseases.
  • Nuances:
    • Overexpression can lead to harmful conditions.
    • CRISPR can cleave genes to stop protein production.
  • Impact on Life: This strategy could significantly reduce disease-related symptoms and improve quality of life for affected patients.

Investments

  • Price: High initial research and development costs.
  • Time: Development and clinical trials required before widespread use.
  • Effort: Requires significant research effort and clinical validation.

Risks

Potential for unintended gene inactivation leading to unforeseen effects.

Alternatives

  • Pharmacological inhibitors to reduce gene expression.

Get Started 🚀

  • Study CRISPR's role in gene inactivation.
  • Identify diseases caused by gene overexpression.
  • Collaborate with research institutions for further exploration.

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Reference Video