CRISPR Targets PCSK9 for Cholesterol Reduction
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Peter Attia MD podcast episode with Feng Zhang
General HealthContent
Story of claim
Feng Zhang explains CRISPR's potential to target the PCSK9 gene using lipid nanoparticles to treat genetic liver diseases and manage cholesterol levels.
- Goal: To treat genetic liver diseases and reduce cholesterol levels using CRISPR.
- Proof: Liver's lipid recycling aids in efficient CRISPR delivery, offering high potential efficacy in liver-targeted therapies.
- Nuances:
- Liver's lipid recycling aids in nanoparticle delivery
- Paralyzing PCSK9 could reduce cholesterol levels
- Impact on Life: Could lead to effective management of liver diseases and cardiovascular risks.
Investments
- Price: Potentially high due to development and clinical testing
- Time: Ongoing research with promising early results
- Effort: Significant due to complexity of delivery systems
Risks
Possible off-target effects and delivery challenges.
Get Started 🚀
- Develop lipid nanoparticle delivery systems
- Target PCSK9 gene to lower cholesterol
- Monitor treatment efficacy and safety
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