Fetal Hemoglobin Expression Reduces Sickle Symptoms
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Peter Attia MD's podcast with Feng Zhang
General HealthContent
Story of claim
CRISPR editing enables fetal hemoglobin expression, reducing sickle cell symptoms. Some individuals with the mutation exhibit alleviated symptoms.
- Goal: To reduce sickle cell symptoms by activating fetal hemoglobin expression.
- Proof: Fetal hemoglobin can mitigate the symptoms of sickle cell anemia by compensating for defective adult hemoglobin.
- Nuances:
- Gene editing focuses on fetal hemoglobin rather than correcting mutation
- Some individuals naturally express fetal hemoglobin and have reduced symptoms
- Impact on Life: Improved quality of life by reducing sickle cell symptoms.
Investments
- Price: Potentially high cost for CRISPR-based treatment
- Time: Ongoing treatment may be necessary
- Effort: Requires careful monitoring and follow-up
Risks
Does not correct the underlying genetic mutation.
Get Started 🚀
- Discuss with a genetic counselor about fetal hemoglobin expression
- Explore CRISPR treatment options with a specialist
- Monitor symptom improvement and adjust treatment as needed
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