CRMs Mimic Fasting to Trigger Autophagy
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Dr. Guido Kroemer on Rhonda Patrick's podcast
Anti-AgingSupplements
Story of claim
Caloric restriction mimetics (CRMs) induce autophagy by simulating fasting's biochemical changes, offering potential anti-aging benefits.
- Goal: Mimic fasting to induce autophagy for health benefits.
- Proof: CRMs induce deacetylation reactions similar to fasting, promoting autophagy.
- Nuances:
- CRMs work through inhibition of Acetyl-CoA generation.
- Spermidine inhibits EP300, crucial for autophagy regulation.
- Impact on Life: Potential anti-aging effects and improved metabolic health.
Investments
- Price: Not mentioned
- Time: Dependent on supplement use
- Effort: Requires consistent use of supplements
Risks
Efficacy in humans not fully established; further research needed.
Alternatives
- Fasting
Get Started 🚀
- Research CRMs like hydroxycitrate and spermidine.
- Consider integrating CRMs into your diet with guidance from a healthcare provider.
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