CRMs Mimic Fasting to Trigger Autophagy

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingSupplements

Quotes From Source

“CRMs induce deacetylation reactions to stimulate autophagy.”

Story of claim

Caloric restriction mimetics (CRMs) induce autophagy by simulating fasting's biochemical changes, offering potential anti-aging benefits.

  • Goal: Mimic fasting to induce autophagy for health benefits.
  • Proof: CRMs induce deacetylation reactions similar to fasting, promoting autophagy.
  • Nuances:
    • CRMs work through inhibition of Acetyl-CoA generation.
    • Spermidine inhibits EP300, crucial for autophagy regulation.
  • Impact on Life: Potential anti-aging effects and improved metabolic health.

Investments

  • Price: Not mentioned
  • Time: Dependent on supplement use
  • Effort: Requires consistent use of supplements

Risks

Efficacy in humans not fully established; further research needed.

Alternatives

  • Fasting

Get Started 🚀

  • Research CRMs like hydroxycitrate and spermidine.
  • Consider integrating CRMs into your diet with guidance from a healthcare provider.

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Reference Video