30% Caloric Restriction Boosts Autophagy

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingDiet

Quotes From Source

“Caloric restriction is 30% less food than normal intake.”

Story of claim

Dr. Kroemer shows that caloric restriction (30% less intake) activates autophagy and stress responses, evidenced by muscle biopsies showing biomarkers like elevated heat shock proteins.

  • Goal: Study the effects of caloric restriction on autophagy and stress response.
  • Proof: Caloric restriction elevates HSP70 by 12-fold, indicating stress response activation.
  • Nuances:
    • Caloric restriction is challenging to maintain in the Western world.
    • Heat shock protein HSP70 elevated by 12 fold in caloric restricted individuals.
  • Impact on Life: Potential for improved longevity and reduced age-related diseases through dietary modulation.

Investments

  • Price: No direct cost, but potential dietary changes
  • Time: Caloric restriction is a long-term commitment
  • Effort: Requires significant lifestyle changes and discipline.

Risks

Sustainability of long-term caloric restriction can be difficult and may lead to nutritional deficiencies.

Alternatives

  • Intermittent fasting for a more flexible approach
  • Dietary interventions targeting specific nutrients

Get Started 🚀

  • Gradually reduce calorie intake by 10% to start.
  • Focus on nutrient-dense foods to avoid deficiencies.
  • Monitor health markers regularly to ensure balanced nutrition.

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Reference Video