CRISPR Memory: Bacteria's Viral Defense Mechanism

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Feng Zhang discusses the mechanism of bacterial defense using CRISPR.

General HealthContent

Quotes From Source

“After first infection, the bacteria is vaccinated against the virus...”

Story of claim

Bacteria use CRISPR and Cas9 to remember past viral infections, allowing them to cut the viral DNA upon reinfection. This process involves acquiring a viral DNA snippet during initial infection, providing immunity against future attacks.

  • Goal: Utilize CRISPR for adaptive immune defense in bacteria.
  • Proof: CRISPR allows bacteria to remember past infections and quickly respond to future attacks.
  • Nuances:
    • Reinfection activates CRISPR RNA with a 30 base guide.
    • Many copies of Cas9 act in parallel to find the match quickly.
  • Impact on Life: N/A

Investments

  • Price: N/A
  • Time: N/A
  • Effort: N/A

Risks

CRISPR may not work against all viruses and requires initial survival of some bacteria.

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