Three Major Pathways Lead to Autophagy Activation

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Dr. Guido Kroemer on Rhonda Patrick's podcast

Anti-AgingTesting

Quotes From Source

“AMP Kinase activated by lower ATP levels induces autophagy.”

Story of claim

Dr. Kroemer outlines AMP Kinase activation, mTOR inhibition, and protein acetylation as key pathways that regulate autophagy, impacting cellular energy and nutrient status.

  • Goal: Understand pathways inducing autophagy.
  • Proof: These pathways regulate autophagy based on cellular energy and nutrient status.
  • Nuances:
    • Acetyl-CoA concentration impacts protein acetylation.
    • Acetyl-CoA reduction causes deacetylation of cellular proteins.
  • Impact on Life: Understanding these pathways could lead to better management of cellular health and longevity.

Investments

  • Price: Estimation: $0, involves understanding natural pathways.
  • Time: Requires ongoing study and understanding.
  • Effort: Effort in research and education about cellular pathways.

Risks

Potential misunderstanding of pathway interactions may lead to incorrect application.

Alternatives

  • Exploration of additional pathways like sirtuins
  • Studying nutrient-sensing pathways

Get Started 🚀

  • Study AMP Kinase, mTOR, and protein acetylation pathways.
  • Incorporate dietary changes to influence these pathways.
  • Consider supplements that affect these pathways, like resveratrol.

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Reference Video